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The problem is that some weapons do not work well with other weapons. One reason for this is that not all weapons scale with every stat. Another reason is that some weapons can lower the efficiency of other weapons to almost zero. A good example of this is Phieraggi and Garlic/Soul Eater. Phieraggi will typically kill enemies before they ever reach the barrier created by the Garlic (or Soul Eater). This list will focus mainly on the standard, non-evolved, weapons, but there will be a few entries featuring evolved weapons on this list.

Updated on September 29, 2022, by Jeff Drake: There are a ton of possible weapon combinations in Vampire Survivors. Some of these combos are downright game-breaking; while some weapons seem to work against each other and make it nearly impossible to last 30 minutes. Some weapon combos don’t work too well on their own, but with the right arcana, the combo becomes overpowered. In light of this, this update expands this list to 15 - which is still barely scratching the surface of great weapon combinations in this game. The option of limiting the number of weapon slots added a new level of difficulty to the game it was needing. The Vampire Survivors’ weapon combinations below can be successful even if they’re the player’s only weapons.

15 Vandalier - Clock Lancet

The problem with Vandalier is the targeting circles that rotate around the character. These targeting circles move a little too fast and have a 1-second cooldown, and as a consequence, the tougher enemies can begin getting through. The Clock Lancet keeps enemies in place long enough to ensure Vandalier’s targeting circles will pass over them.

The Out of Bounds arcana takes this combo up a tier or two, and the Gemini arcana will give the player Vandalier’s twin as a free weapon. The Empty Tome and Spellbinder passive items should be selected; these will make the Clock Lancet rotate faster and Vanadlier’s attack last longer.

14 Holy Wand - Gorgeous Moon - Laurel

This combo is a little tricky getting them to the point the weapons can be evolved. That’s why the Laurel is included - insurance. Once the Magic Wand and Pentagram are evolved they can keep even the strongest enemies at bay. At the start of a run with this combo, the player will have to stay on the move, and getting the Attractorb doesn’t hurt. With the Holy Wand and Gorgeous Moon, the player can sit the controller down.

This combo is made exponentially better with the Waltz of Pearls arcana. This makes the Holy Wand act like three weapons and makes the wands better when surrounded on all sides. Evolving the Laurel is not necessary, since the enemies won’t be getting near the character by the time it is ready to evolve.

13 La Robba - Bracelet

The La Robba can be used solo and still feel overpowered. It really doesn’t need any help, but an excellent secondary weapon to go with La Robba is the Bracelet. La Robba hurls furniture from the top of the screen; though, they normally spawn closer to the center of the screen rather than the corners.

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The Bracelet sends out missile-looking projectiles that reach the edge of the screen and create harmful zones for the enemy to pass through. The La Robba protects the center of the screen, while the Bracelet protects the edges. Good passive items with this combo are the Duplicator, Spinach, Torrona’s Box, Candelabrador, and Empty Tome.

12 Carrello - Vento Sacro

Some weapons are built for moving to the left or right indefinitely. The combo of Carrello and Vento Sacro puts two of the best of this type together. When fully leveled, this combo will allow for uninterrupted walking to the left or right; making it the perfect build for the Inlaid Library.

This loadout is improved with the Tragic Princess arcana. This will greatly reduce the cooldown time of the Carrello as long as the character is moving. The Spinach, Bracer, Wings, and Candelabrador passive items also improve this combo. It never hurts to get the Attractorb passive item with builds designed for constant lateral movement. Focus on Area when limit breaking the Carrello.

11 Vicious Hunger - Vandalier

Make no mistake, the Vicious Hunger and Vanadlier are one of the best Vampire Survivors combinations; however, Gatti Amari, Peachone, and Ebony Wings are a tough combo with which to survive. This combo demands the Gemini arcana- effectively giving the player four weapons for the price of two.

The best passive items with this combo are Empty Tome, Torrona’s Box, Spinach, Clover, and Stone Mask. The Disco of Gold also works well with this combo, it can make the player a lot of gold and heal the player at crucial moments. This is a challenging combo to maximize, but once it is the player can easily survive to the 30-minute mark.

10 Garlic - King Bible

The Garlic - King Bible combination is one that has been available since Vampire Survivors’ release, and it continues to be one of the best combinations. The King Bible creates books that spin around the character. These books do an average amount of damage (10), but due to their spinning nature, an enemy will usually be hit by multiple books.

The Garlic creates a circular barrier around the character that damages enemies if they enter. The King Bible’s radius is slightly further than the Garlic; which creates two barriers that enemies must pass through to get to the character.

9 Song Of Mana - Knife

Most weapons in Vampire Survivors have a horizontal firing pattern; the Song of Mana is one of the few that extends vertically. Due to this weapon’s vertical attack, it’s quite effective at clearing the screen of enemies as the character walks to the left or right. This is especially true when both weapons are fully leveled and boosted by the Spinach passive item.

As enemies become stronger the Song of Mana becomes too weak to continuously walk to the left or right; enemies will start reaching the character through the Song of Mana and cause damage. The Knife negates this weakness by clearing a path through the enemy.

8 Santa Water (La Borra) - Runetracer

The Santa Water starts incredibly weak, but by Level 8 it becomes one of the more powerful weapons. Its evolved form, La Borra, is arguably the best weapon in the game. The only problem with La Borra is that it only covers the center of the screen, or more precisely, the area around the character.

The Runetracer sends out diamond projectiles that pass through enemies and bounce off of walls and the edge of the screen. This forces enemies to take damage as soon as they enter the screen. First, the enemy must pass through the Runetracer projectiles. If they survive this they will certainly be taken down by the La Borra as they get closer to the character.

7 Celestial Dusting - Shadow Pinion

The Celestial Dusting and Shadow Pinion operate similarly. Both of these weapons send projectiles away from the character in the opposite direction they’re walking. This type of weapon takes a little while to get used to but can be incredibly effective against the bosses in the game.

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These two weapons give the character the ability to attack enemies approaching from behind. When combined, these two give unparalleled protection against pursuing enemies. Additionally, enemies have a natural tendency to start forming a single file line when chasing the player.

6 Vento Sacro - Knife

The Vento Sacro is the newest weapon introduced into the game, and what it lacks in damage per hit it makes up for with a blazing-fast attack pattern that delivers numerous hits in less than a second. This weapon fires in whatever direction the character is facing, much like the Knife.

By combining the Knife and Vento Sacro the player can walk endlessly to the left or right with little chance of anything but a boss creature being able to reach them. The evolved form of these weapons works even better together, thanks to Fuwalafuwaloo’s (Vento Sacro) life-stealing properties, and Thousand Edge’s continuous rate of fire.

5 Bone - Cherry Bomb

These two weapons are among the rarest in Vampire Survivors - that must mean they’re pretty good. Spoiler…they are. Both of these weapons’ projectiles bounce off of enemies. They are both listed as having a base damage of 8, but they seem to be more powerful than this while playing.

Towards the end of a stage, when the enemies begin surrounding the character on all sides, is when these two weapons shine. The ever-tightening circle of enemies around the player causes these weapons to become much more efficient. This is because the distance the projectiles have to travel between bounces is lessened, and there is almost zero chance of missing.

4 Cross (Heaven Sword) - Lightning Ring

The Lightning Ring, and its evolved form (Thunder Loop), hits wide swathes of the battlefield. This weapon also does an impressive amount of damage; only two of the standard weapons, the Axe and Fire Wand, do more damage than the Lightning Ring.

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The Cross isn’t nearly as damaging, but it makes up for this by sending out multiple projectiles and passing through enemies. The evolved Cross, the Heaven Sword, is also one of the most damaging weapons in the game. Combining these two weapons gives the player enough firepower to clear the enemies from the screen as fast as they can appear - at least until around the 20-minute mark.

3 Mannajja - Holy Wand

The Mannajja is the evolved form of the Song of Mana and functions much like its lesser form. The biggest difference is that the Mannajja has a chance of slowing enemies caught in its shockwave. The Holy Wand is the evolved form of the Magic Wand. This is a rapid-fire weapon that targets the nearest enemy.

Any enemy not killed by the Mannajja will be slowed (hopefully) and weakened. These slowed, weakened, enemies are quickly destroyed by the constant firing of Holy Wand. The Empty Tome evolves the Magic Wand into the Holy Wand, but this passive item also works well with the Song of Mana and Mannajja.

2 Death Spiral - Phieraggi

Once a player evolves the Axe into the Death Spiral and merges Eight the Sparrow and Phiera Der Tuphello, they can set the controller down and watch. Seriously, these two weapons sweep across the battlefield, leaving only the strongest of enemies standing - for a couple of seconds anyway.

This combination works well due to the 360° coverage of both weapons. This combo is made even better due to both weapons scaling almost identically to each other; both weapons scale with every stat except duration. Use these two with the Empty Tome, Bracer, and Duplicator passive items to unleash an unending wave of death and destruction upon the enemy.

1 Bloody Tear - Crimson Shroud

This is perhaps the best weapon combination in the game. The reason for this is simple - this combination of evolved weapons makes the character (nearly) unkillable. The Crimson Shroud limits how much damage the character can take, and when this limit is reached the character is made invulnerable for a short period.

The Bloody Tear has life-stealing properties; meaning the character is healed when damaging the enemy. The combination of these two weapons, along with the Clock Lancet, allows the player to laugh at Death when the timer hits the 30-minute mark. Thanks to the Crimson Shroud, most enemies simply can’t do enough damage to the player to overcome the healing of the Bloody Tear.

Vampire Survivors is available now on PC and macOS.

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